You wrote: "As someone with a loved one who does have PASC/Long-COVID, I sorta know it when I see it but many of her doctors were stymied as to whjat to call it or what to do. In other words, we’re still learning."
I'm curious what kind of treatment your loved one has received for long-COVID, and if they got COVID before their COVID vaccines or afterwards. I read the government spent millions studying long COVID, but came up with nothing regarding what to do about it. Are there groups of doctors sharing their long COVID treatments and learning from each other how to treat long COVID? When long COVID was first recognized, the only treatment offered in clinics I read about was just physical therapy.
One point of clarification… at the time the vaccine studies were being carried out, the pandemic wasn’t exactly in full swing, and if I recall correctly there were doubts expressed that enough incident covid infections would occur in both control and intervention groups to reach a clear cut, timely answer.
New cases had dropped back significantly from the April surge, and restrictions and lockdowns meant far lower cases were being seen than was earlier forecast by the researchers. Things picked up as infections rose in the summer, but mainly in states that had rescinded restrictions more than others.
One very erudite and provocative article exquisitely describing Pfizer and Moderna’s modification of the antigenic spike protein for the mRNA vaccines to render them immunologically acceptable. This paper and the conclusions made by the authors from Oxford and Cambridge provide reasonable cause and data-driven reasons why an increasing percentage of the population has begun to question the risk/benefit of acquiescing to more booster vaccines. Perhaps many of those disinclined aren’t all alarmists or anti-vaxxers. Perhaps they are more well-versed than the average agent representative from the CDC, FDA or IDSA Fellow. These are critically important conclusions and I for one could never accept a for-profit Pharma’s opinion that the product they are promoting is, perhaps, 99.9% safe and that idiotypic antibodies aren’t an issue when altered antigenic proteins are introduced more than once in a pandemic scenario. It simply defies belief that everyone that declines is ignorant of the consequences of immune stimulation by foreign material. Oh, to be clear, my spouse and I are fully vaccinated and boosted. I simply choose to keep an open mind and also believe that treating the SARS-COV2 virus with a pure antiviral like Paxlovid within 5 days of symptoms does NOT address the virus’ downstream targets. My in-depth research and clinical experiences dealing with issues with the critical a7 neurotransmitter receptors has concluded that the virus has the overwhelming advantage of infecting and disseminating way before the infection manifests itself or the individual realizes he/she is a victim. An immune modulator that addresses the antigen-antibody cascade is a far better bet if I needed a durable therapy. Using a repurposed, efficacious, durable and safe drug that isn’t priced like a Pharma blockbuster makes it an even better choice. Those that have had no vaccine would do well to at least get a basic 2 shots given the significant jump in cases and the only monitoring left on the table, wastewater monitoring.
Your masking plea as part of a multi layer approach for prevention was well stated Dr Creager. If you have followed some of my previous comments fbo viewers concerns and questions, you might have noted my focus on repurposed drugs and the issues surrounding the two most infamous therapies based upon Hydroxychloroquine and ivermectin. They are both dead in the water
A distillation of our four years of clinical experience and my personal efforts with clinical research has been distilled in the following articles you might find worthy of your time. A recent one focusing on PASC is still in review by the publisher, but it focuses on a credible therapy for and I think you will find it especially meaningful since you mentioned a loved one with this complication from SARS-Cov2 exposure.
Ref #1 Foster, M.R.B., Hijazi, A.A., Sullivan, R.C., Opoku, R. (2023). Hydroxyurea and pyridostigmine repurposed for treating
Covid-19 multi-systems dysfunctions. AIMS Medical Science. 10(2), 118-129.
I can tell you anecdotally that several people with PASC have had a remarkable response to 2 repurposed pharmaceuticals. The drugs have a long history of safety and utility for other purposes (by definition). The details of the pharmacodynamics of HU and rivastigmine are readily available.
You wrote: "As someone with a loved one who does have PASC/Long-COVID, I sorta know it when I see it but many of her doctors were stymied as to whjat to call it or what to do. In other words, we’re still learning."
I'm curious what kind of treatment your loved one has received for long-COVID, and if they got COVID before their COVID vaccines or afterwards. I read the government spent millions studying long COVID, but came up with nothing regarding what to do about it. Are there groups of doctors sharing their long COVID treatments and learning from each other how to treat long COVID? When long COVID was first recognized, the only treatment offered in clinics I read about was just physical therapy.
One point of clarification… at the time the vaccine studies were being carried out, the pandemic wasn’t exactly in full swing, and if I recall correctly there were doubts expressed that enough incident covid infections would occur in both control and intervention groups to reach a clear cut, timely answer.
New cases had dropped back significantly from the April surge, and restrictions and lockdowns meant far lower cases were being seen than was earlier forecast by the researchers. Things picked up as infections rose in the summer, but mainly in states that had rescinded restrictions more than others.
https://www.nature.com/articles/s41586-023-06800-3.pdf
One very erudite and provocative article exquisitely describing Pfizer and Moderna’s modification of the antigenic spike protein for the mRNA vaccines to render them immunologically acceptable. This paper and the conclusions made by the authors from Oxford and Cambridge provide reasonable cause and data-driven reasons why an increasing percentage of the population has begun to question the risk/benefit of acquiescing to more booster vaccines. Perhaps many of those disinclined aren’t all alarmists or anti-vaxxers. Perhaps they are more well-versed than the average agent representative from the CDC, FDA or IDSA Fellow. These are critically important conclusions and I for one could never accept a for-profit Pharma’s opinion that the product they are promoting is, perhaps, 99.9% safe and that idiotypic antibodies aren’t an issue when altered antigenic proteins are introduced more than once in a pandemic scenario. It simply defies belief that everyone that declines is ignorant of the consequences of immune stimulation by foreign material. Oh, to be clear, my spouse and I are fully vaccinated and boosted. I simply choose to keep an open mind and also believe that treating the SARS-COV2 virus with a pure antiviral like Paxlovid within 5 days of symptoms does NOT address the virus’ downstream targets. My in-depth research and clinical experiences dealing with issues with the critical a7 neurotransmitter receptors has concluded that the virus has the overwhelming advantage of infecting and disseminating way before the infection manifests itself or the individual realizes he/she is a victim. An immune modulator that addresses the antigen-antibody cascade is a far better bet if I needed a durable therapy. Using a repurposed, efficacious, durable and safe drug that isn’t priced like a Pharma blockbuster makes it an even better choice. Those that have had no vaccine would do well to at least get a basic 2 shots given the significant jump in cases and the only monitoring left on the table, wastewater monitoring.
Of interest...
https://www.powerlineblog.com/archives/2024/01/whole-lotta-lyin-goin-on-3.php
..credible therapy for PASC (inexplicably truncated)
Your masking plea as part of a multi layer approach for prevention was well stated Dr Creager. If you have followed some of my previous comments fbo viewers concerns and questions, you might have noted my focus on repurposed drugs and the issues surrounding the two most infamous therapies based upon Hydroxychloroquine and ivermectin. They are both dead in the water
A distillation of our four years of clinical experience and my personal efforts with clinical research has been distilled in the following articles you might find worthy of your time. A recent one focusing on PASC is still in review by the publisher, but it focuses on a credible therapy for and I think you will find it especially meaningful since you mentioned a loved one with this complication from SARS-Cov2 exposure.
Ref #1 Foster, M.R.B., Hijazi, A.A., Sullivan, R.C., Opoku, R. (2023). Hydroxyurea and pyridostigmine repurposed for treating
Covid-19 multi-systems dysfunctions. AIMS Medical Science. 10(2), 118-129.
Ref #2 Moftah and Eswayah
https://www.sciencedirect.com/science/article/abs/pii/S0306987723000178
Repurposing of Hydroxyurea Against COVID-19: A Promising Immunomodulatory Role. - Abstract - Europe PMC
Ref #3 https://www.sciencedirect.com/science/article/pii/S0165572823002308
Ref #4: (preprint)
https://www.qeios.com/read/DTA98L
I can tell you anecdotally that several people with PASC have had a remarkable response to 2 repurposed pharmaceuticals. The drugs have a long history of safety and utility for other purposes (by definition). The details of the pharmacodynamics of HU and rivastigmine are readily available.